After the events of the final confrontation in Raccoon City, Alice finds herself in an even darker and more dangerous world. The zombie apocalypse has left deep scars on humanity, and now she must face not only zombies but also a variety of monsters known from the Resident Evil saga.

As she travels through devastated cities, infested forests, and abandoned facilities, Alice encounters terrifying mutant creatures. Among them are the fearsome Lickers, agile and bloodthirsty creatures that lurk in the shadows; the dreaded Nemesis, relentless biological killers created by the Umbrella Corporation; and the grotesque Tyrants, unstoppable destroying monsters.

In her quest for survival and justice, Alice meets other brave survivors who also fight against the nightmare creatures. Together, they form an unlikely team, each bringing their own skills and knowledge to the group.

In the end, as the sun rises on a new day, Alice and the remaining survivors unite to rebuild a world devastated by the biological threat. Hope is reborn, but the fight against evil is far from over.